Anti D Immunoglobulin (Polyclonal)

Anti-D Immunoglobulin (Polyclonal) is a blood product used in medicine to prevent Rh(D) hemolytic disease of the newborn (HDN) and other complications related to Rh(D) incompatibility during pregnancy. It is also known as Rh(D) immune globulin.

Rh(D) incompatibility occurs when a pregnant woman who is Rh(D)-negative carries a baby who is Rh(D)-positive. If fetal blood enters the mother's circulation during pregnancy or childbirth, the mother's immune system may produce antibodies against the Rh(D) antigen, which can pose a risk to subsequent pregnancies. These antibodies can cross the placenta and attack the red blood cells of an Rh(D)-positive fetus in subsequent pregnancies, potentially leading to hemolytic disease of the newborn.

Anti-D Immunoglobulin is made from the plasma of donors who have high levels of antibodies against the Rh(D) antigen. When administered to an Rh(D)-negative mother, Anti-D Immunoglobulin binds to any Rh(D) antigens that may have entered her bloodstream during pregnancy or childbirth. By doing so, it prevents the mother's immune system from producing its own antibodies against Rh(D) and helps to prevent sensitization, thereby reducing the risk of HDN in future pregnancies.

• 1-Indications: Anti-D Immunoglobulin is primarily used in Rh(D)-negative pregnant women to prevent the development of Rh(D) antibodies and HDN when they are exposed to Rh(D)-positive fetal blood during pregnancy, childbirth, or other procedures (e.g., amniocentesis, miscarriage).
• 2-Administration: Anti-D Immunoglobulin is typically administered by injection into the mother's muscle (intramuscular) after specific pregnancy-related events, such as around 28 weeks of gestation, within 72 hours of childbirth or other events that may lead to fetal blood exposure.
• 3-Effectiveness: When administered appropriately, Anti-D Immunoglobulin is highly effective in preventing Rh(D) sensitization and its associated complications.
• 4-Safety: The risks of using Anti-D Immunoglobulin are generally low. Some women may experience minor side effects at the injection site, such as redness or swelling. Severe reactions are rare.

It's important for Rh(D)-negative pregnant women to receive appropriate prenatal care and discuss the need for Anti-D Immunoglobulin with their healthcare provider to ensure the best possible outcome for both the current and future pregnancies.